Success in this project will uncover an entirely new class of chemotherapeutics to fight ovarian cancer. To determine if newborn hippocampal maturation is predictive of 12-month memory outcomes. We hypothesize that health is characterized by robust entropy production at rest combined with the ability to further elevate it in response to exercise or heat stress (i.e. both function & adaptability).

This is largely because many questions remain about the mechanisms of action of DBS (i.e. how it modulates neural activity). However, new work unequivocally demonstrates that the effects of DBS on neuronal activity, evoked responses, and brain oscillations vastly differ on a structure-to-structure basis and depending on the applied stimulation settings. Evidence in humans suggests that DBS can up- or downregulate neuronal output, amplify or suppress evoked fields and oscillations, and potentiate or depress synaptic transmission fidelity (i.e. elicit long-term plasticity; LTP). Interrogation of individual IcNS contributors and interconnectivity using novel optogenetic techniques for regional, cell-specific manipulation, combined with 3D cell-resolution imaging of IcNS and cardiac structure.

NMC476H1 – Politics of Archaeology in the Modern Middle East

The course is designed to re-examine the role of intellectuals in the Arab world and political events that shaped their thinking. It introduces the life and thought of some leading thinkers of the Arab world and relates their thought to the lived experience of political, social, economic and cultural change in the Middle East. This course explores further applications of polarized-light microscopy in the examination of archaeological materials, particularly pottery . Class and lab discussions will include critical examination of the application and integration of ceramic petrology in archaeological research design and how petrology can address relevant research questions successfully.

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• Red Wilson’s latest gift to McMaster – $2.5 million – is a catalyst for revitalizing the study and promotion of Canadian history, an area where Wilson has established himself as a champion.
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• Their gift of $6 million provided the funds needed to secure approval for construction after decades of anticipation and years of planning.
• This course examines the relationship between political critique and the textual production of possible worlds, taking the Arabic literary canon as its example.

The course is concerned with the political and cultural history of ancient Israel and the Hebrew people from origin stories set in the pre-monarchic period to early Roman Palestine. Israel is the land that bequeathed the Bible, the Jewish people, and hosted the birth of Christianity. Much of its history witnessed hostile interactions with imperial forces, from Babylon to Rome. The course explores issues related to gender within the ancient Egyptian context and investigates the activities of women through the study of many different kinds of archaeological and material evidence. We’ll build a foundation for this work with an overview of current developments in gender theory and consider their applications for research on ancient Egyptian society and culture. The same methods of critical analysis will inform our study of women in ancient Egypt, incorporating archaeological data and artifactual material that can inform our understanding of the complex roles that women played in Egyptian culture, society, and religious practice.

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Language and Literature Courses

Egypt is one of the oldest known civilizations on the African continent. Deeply embedded within early African history, Egypt was also inextricably linked with the history of many civilizations in the Ancient Near East. Emphasis will be placed on the methods by which knowledge about this ancient civilization can be obtained. Popular conceptions of enslavement in North America have influenced how we frequently imagine enslavement in Exodus and related biblical and related texts from the ancient Near East. Yet, depictions of enslavement in these ancient texts may be strikingly different from our ideas of enslavement in North America. This course explores similarities and differences between enslavement in these different historical contexts.

This will produce new treatments for gastric cancer which is the third leading cause of death from cancer. TS-Apt will solve the problem of genome wide inhibition of DNMT caused by existing DNMTi. The novel interdisciplinary approach combines experts in, drug discovery, to design and test the TS-Apt, nanoparticles, to formulate TS-Apt into NP, and epigenetics, to show that the effects of TS-Apt are confined to the p16 gene. If our hypothesis on cerebellar function is correct, the contribution to science would be seminal. We are pursuing an alternative hypothesis on cerebellar function motivated by ideas from control theory.

The project also attracted a significant number of private contributions including the $10 million gift from Ron Joyce that named the centre. The McMaster Museum of Art – which moved to its current world-class facility in the Alvin A. Lee Building in 1994 – has long depended on the generosity of private donors to build one of the great university-based art collections in Canada. The nearly 6,000 works in the museum’s permanent collection feature particular strengths in early twentieth-century German Expressionist art, contemporary Canadian art, and modern and contemporary European art. Donations of both cash and art have driven the growth and quality of the permanent collection – most notably through the visionary donation from Hamilton businessman Herman H. Levy. McMaster’s first graduates were the 16 members of the Class of 1894.

In order to contextualize different ways of thinking about other worlds, we also look at cross-cultural comparisons ranging from Africa to the Americas. From 2500 to 333 BCE, the ancient Near East saw the world’s first empire, the birth of international diplomacy, burgeoning sea-trade and piracy, perennial warfare and the emergence of new ethnic identities like the Philistines and Israelites. Explore the archaeological evidence for these events in Mesopotamia, Egypt, Anatolia and the Levant. This is an experiential course that asks what it would have been like for people in the ancient Near East as their world underwent the profound changes wrought by domestication, farming, urbanism, and state formation. We focus on the sensory experiences of the body, and their effect upon the mind, by reconstructing and using spaces and objects that have come to define the archaeological periods from 10,000 to 2500 BCE.

The donation also created a new fund to seed high-potential medical research within the Faculty of Health Sciences. The fund reflects Dr. DeGroote’s passion for innovative risk taking and supports the most promising avenues of discovery, helping breakthroughs move more quickly from labs to clinical application. One of the most transformative gifts of McMaster’s Centennial Campaign was Michael G. DeGroote’s 1987 gift of $3 million to the Faculty of Business. Dr. DeGroote not only provided the keystone gift, but advocated for additional support of the faculty from other donors.

It will also look at the shortcomings of contemporary academic research on Babylon, and how difficult it is to reconstruct humankind’s distant past. Persian women born in the late 19th century and first half of the 20th century were products of a period of major social and cultural change. For the first time, an educated female could envision a life beyond the conservative ideal of a woman’s proper place in the home. We will use memoirs of women who were able to contribute to Iranian society and interviews with women whose ambitions were inhibited or repressed by the dominance of patriarchal culture.

NMC264H1 – The Archaeology of Stuff

This course is an introduction to the exegetical methods of the rabbinic sages in their analysis of biblical texts, with special attention to issues of intertextuality. After a quick overview of the genres of midrashic literature, we shall examine the midrashic methods used to transition from the biblical text to the midrash. Our main focus will be on Original Sin in the Garden of Eden and its repercussions. Our primary texts will be Bereishit Rabbah, Avot de Rabbi Natan, and Alphabeta deBen Sirah.

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Students will experiment with appropriately using concepts from modern critical theory in the analysis of premodern and modern Arabic literary texts. Readings include Qur’anic apocalyptic suras, the philosophical novel Hayy ibn Yaqzan, Sindbad the Sailor and other travel narratives, al-Maʿarri’s satirical narrative of a visit to the afterlife, trickster tales of the maqama genre. We then turn to the merging of novelistic forms, selfhoods, and conceptions of political organization with those of the maqama in early novels by al-Muwaylihi and al-Shidyaq, ending with contemporary conceptual art and a dystopic novel. This course offers an introduction to the development of early bureaucracies in ancient Mesopotamia , Iran and Syria.

NMC480H1 – Structural Development of the Iranian Languages

The strength, duration and combination of induced reflexes will be modulated to recreate limb actions, such as postural maintenance, leg extension and gait. Proprioceptive signals will be measured from the dorsal columns by recording local field potentials and transmitted back to the glove as vibration patterns to refine motor control. This is a high-risk project with the potential for high-reward, as it will be the first study of its kind focused on failure to launch in young Black men, with the grassroots community partner driving project progress throughout.

NMC497H1 – Independent Studies

We will discuss examples from Nigeria to Somalia, Egypt, Turkey, and Iran, to India, Pakistan, and Indonesia, to Canada, the US, and Europe. Students will apply anthropological methods learned in class to do research among a Muslim community in Toronto or online. Topics include the Nizam-i Cedid , the Tanzimat, the Hamidian era, the Young Turk revolution, constitutionalism, women, and the emergence of artistic expressions of modernity, such as theatre and painting. The course also provides insights into the Ottoman legacy in modern ez coin ranking Turkey, the Middle East, and the Balkans, and seeks to situate the Ottoman experience in a global context. It provides students with an in-depth knowledge of the grammar of the language focussing on the areas of phonetics, phonology, morphology, syntax, and the interaction between phonology and morphology. The course will introduce students to the Christian communities living in the Middle East since the distant past, identified by ecclesiastical and or ethnic terms, including Armenian, Copt, Greek-Melkite, Maronite, and Syriac.

This course examines the role nineteenth and twentieth-century archaeology played in Middle Eastern politics, the culture of colonialism and in nationalist struggles. The course will first familiarize the students with the diplomatic and intellectual context of the formation of archaeology as a field of study in Europe and analyse the role archaeology played in the production of knowledge about the Middle East. Next, the course will examine the archaeological practices on the ground and inquire what happens in the contact zone between foreign and local archaeologists. Finally, we will trace the ways in which emergent nationalist discourse challenge, appropriate and imitate the historical narratives of Western archaeology. This course will examine certain aspects of status and family law in Judaism, as well as Zoroastrianism, Eastern Christianity, and Islam.